Bethesda, MD 20892, Exvivo Human Tissue Model: Hernandez Lab Research Interests. Current efforts are focused on elucidation of mechanisms and signal transduction pathway involvement for the identified genes of interest, to unveil clinically translatable targets. Jonathan Hernandez Texas Rangers #72 Relief Pitcher Follow HT/WT 6' 2", 175 lbs DOB 7/6/1996 (24) BAT/THR Right/Right Birthplace Memphis, TN Status Active 2020 season stats SV 0 … The reasons for the inadequacies of these model systems, which are largely based upon cell lines, mouse models, or patient-derived xenografts, are myriad, but are almost certainly related to the absence of the human stromal component and its intricate relationship with tumor cells. He specializes in the treatment of pancreatic tumors and tumors of the liver and bile ducts. View Dr. Hernandez's Complete Bibliography at NCBI. The lab has utilized complex cDNA and CRISPR-Cas9 screens to identify genes that conspire to drive the outgrowth of disseminated tumor cells, which ostensibly appear to be involved in epigenetic reprogramming, compensatory metabolism, and extracellular matrix deposition and remodeling. The NIH Clinical Center, located in Bethesda, Maryland, is the world’s largest hospital fully dedicated to clinical research. Through clinical research, promising discoveries in the laboratory are translated into better health and health care for all. However, the potential exists for a new model of human malignancy. Dr. Hernandez’s research program focuses on interrogating the molecular underpinnings of metastatic colonization in order to interrupt the process prior to its completion. National Institute of Biomedical Imaging and Bioengineering (NIBIB) Our Mission As a hepatobiliary oncologic surgeon, my lab has unparalleled access to tumor-bearing human tissue directly as it is removed from a patient’s body and transferred to the perfusion machine. Survival after pancreaticoduodenectomy is not improved by extending resections to achieve negative margins. The Institute is committed to integrating the physical and engineering sciences with the life sciences to advance basic research and medical care. Our interpretation is that the currently available model systems lack the appropriate clinical predictive power. To discuss more specifics of this summer project, please feel free to contact Dr. Jonathan Hernandez. 2009;250(1):76-80. Hernandez JM, Tsalatsanis A, Humphries LA, Miladinovic B, Djulbegovic B, Velanovich V. Hernandez J, Mullinax J, Clark W, Toomey P, Villadolid D, Morton C, Ross S, Rosemurgy A, New clinical program will study metastatic colorectal cancer in viable patient tissue samples, Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal Cancers, A Single-Arm Phase II Study of Hepatic Artery Infusion Pump Chemotherapy with Floxuridine and Dexamethasone in Combination with Systemic Chemotherapy for Patients with Colorectal Cancer Metastatic to the Liver. University of South Florida General Surgery Residency, University Hospitals Case/Western Reserve University Medical Center General Surgery Residency, Matched: Complex General Surgical Oncology at M.D. Finally, immunomodulatory agents will be directly assessed, which may provide a much-needed avenue of advancement our understanding about why some patients respond while others do not. 2015;17(6):816-26. Read more... On Wednesday, Nov. 29, 2017, NIH Foregut Team members presented information and answered questions during a webinar on stomach cancer treatment options. Survival after pancreaticoduodenectomy is not improved by extending resections to achieve negative margins. Access the recorded webinar. The NIH Clinical Center Patient Portal is a secure website that connects you to important resources. PubMed PMID: 31749079. The Patient Portal is designed to provide you with access to key medical information regarding care you received at the Clinical Center, including test results. Since 2005, ex vivo perfusion has been used to bridge organs from donation to transplantation. He specializes in the treatment of pancreatic tumors and tumors of the liver and bile ducts. The clinical trials at the NIH Clinical Center are predominantly Phase I and Phase II, often first-in-human to test safety and efficacy. Dr. Hernandez has authored over 100 peer-reviewed publications and has contributed book chapters in numerous authoritative surgical textbooks. We use the tumors removed during surgery in our novel ex vivo systems, which allow us to keep your tumor alive for several days. COVID-19 is an emerging, rapidly evolving situation. Affiliations 1 Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. We can envision a fundamental alteration in drug development such that efficacy is evaluated first, rather than last, with subsequent efforts focused on delivery techniques and minimization of toxicity. The mission of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) is to improve health by leading the development and accelerating the application of biomedical technologies. Surgical Oncology Program Metastasis Biology Section, Microfabrication and Microfluidics Unit, Biomedical Engineering and Physical Science Shared Resource, U.S. Department of Health & Human Services, Get the latest public health information from CDC, Get the latest research information from NIH, NIH staff guidance on coronavirus (NIH Only), RADx Tech Programmatic or Technical Inquiries, Biomedical Engineering Summer Internship Program (BESIP), https://ccr.cancer.gov/surgical-oncology-program/jonathan-m-hernandez, https://www.nibib.nih.gov/labs-at-nibib/trans-nih-shared-resource-biomedical-en…. design software applications to assimilate the data. During his fellowships, Dr. Hernandez spent an additional two years in dedicated basic research studying metastatic colonization as a scholar in the Cell Biology Program of the Sloan Kettering Institute supported by NIH funding and a grant from America’s HepatoPancreatoBiliary Association. This line of investigation corresponds with a critical need in biomedical research, as metastases are the cause of greater than 90% of cancer related deaths. placement of additional sensors for increased real-time hemodynamic and biochemical analysis. Jeremy Davis, M.D., Staff Clinician in the CCR Thoracic and Gastrointestinal Oncology Branch, and Theo Heller, M.D., Senior Investigator in the National Institute of Diabetes and Digestive and Kidney Diseases, joined David Fogel, a recent total gastrectomy patient, to discuss the latest advancements in treatment. Dr. Hernandez’s research program focuses on interrogating the molecular underpinnings of metastatic colonization in order to interrupt the process prior to its completion. Okada T, Sinha S, Esposito I, Schiavon G, López-Lago MA, Su W, Pratilas CA, Abele C, Hernandez JM, Ohara M, Okada M, Viale A, Heguy A, Socci ND, Sapino A, Seshan VE, Long S, Inghirami G, Rosen N, Giancotti FG. The tissue specimen is maintained at normothermia (37⁰C) while our team performs hourly point of care labs on the tumor-bearing organ and adjusts the perfusate composition accordingly.